Superdisintegrants market: Enhancing the development and formulation of fast-dissolving tablets
Superdisintegrants are added to drug formulation in order to facilitate the dissolution of tablet or capsule content into reduced particles. It is usually used in lesser quantities in the solid dosage form, typically ranging from 1–10% by weight, which is relative to the total weight of the dosage unit. Some of the widely used products include crospovidone, croscarmellose sodium and sodium starch glycolate. Crospovidone is capturing the major chunk of the market revenue due to high capillary activity, pronounced hydration capacity and its least tendency to form gels.
With the increasing demand for solid dosage form in the healthcare industry, the market for superdisintegrants will continue to rise. In addition, governments of various countries are focusing on prevention rather than treatment, which would increase the consumption of pharmaceutical, and hence boosting the growth of the market. Furthermore, advanced research and development pertaining to superdisintegrants is also anticipated to drive the market growth.
According to various research studies, natural superdisintegrants such as gellan gum, ispaghulla, gum karaya, fenugreek seed mucilage, and others have various advantages over the synthetic ones. They are chemically inert, inexpensive, biodegradable, non-toxic and widely available. It can also be altered in different ways to achieve tailor- made materials for the best drug delivery systems, which can compete with the available synthetic excipients.
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Novel drug delivery system currently aims to enhance safety by the formulation of a convenient dosage form. For instance, formulation of orally disintegrating tablets are useful for pediatric, geriatric and also dysphagic patient population, hence leading to improved patient compliance. Few conventional techniques used for the manufacture of orally or fast disintegrating tablets are Zydias technology, Durasolv technology, flash dose technology and others.
Superdisintegrants are used as viscosity enhancing agents in drug loaded films, former having superior performance over the later. Moreover, addition of superdisintegrants have resulted in high drug content uniformity and nanoparticle surface area retention. Hence, the use of superdisintegrants have proved to be economical, and one of the superior alternatives to traditional viscosity enhancing agents.
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